COVID-19 mRNA Vaccines: From Inflammation to Hyperinflammation (preprint)

Each injection of any known vaccine results in a strong expression of pro-inflammatory cytokines. This is the result of the innate immune system activation, without which no adaptive response to the injection of vaccines is possible. COVID-19 mRNA vaccines would not escape this rule. Unfortunately, the degree of inflammation produced by these vaccines is variable, probably depending on the genetic background and previous immune experiences, which through epigenetic modifications, could have made the innate immune system of each individual tolerant or reactive to subsequent immune stimulations.We hypothesize that we can move from a limited pro-inflammatory condition to conditions of increasing expression of pro-inflammatory cytokines that can culminate in multisystem hyperinflammatory syndromes following COVID-19 mRNA vaccines (MIS-V). We have graphically represented this idea in a hypothetical inflammatory pyramid (IP) and we have correlated the time factor to the degree of inflammation produced after the injection of vaccines. Furthermore, we have placed the clinical manifestations within this hypothetical IP, correlating them to the degree of inflammation produced. Surprisingly, excluding the possible presence of an early MIS-V, the time factor and the complexity of clinical manifestations are correlated to the increasing degree of inflammation: symptoms, heart disease and syndromes (MIS-V).

COVID-19 Italian epidemic: quarantine with continuous spillover. (preprint)

Background. In December 2019, an epidemic started in China caused by a new coronavirus (SARS-CoV-2), probably derived from bats. The Italian COVID-19 epidemic begins on February 21, 2020. Methods. We have collected and analyzed the data produced daily by the Civil Protection. We cataloged this data and produced tables and graphs to obtain dynamic curves for certain parameters. In addition, we also calculated the change in active cases with the following formula: (newly infected) - (new deaths) - (new recoveries). Findings. The number of total cases increased by about 40 times in the period 2-20 March (from 2,036 to 80,539). In the same period, the active cases increased by about 21 times (from 1,835 to 37,860). Active cases do not close quickly and remain open for a long time because those who enter in intensive care do not recover before 2-3 weeks. On March 19 Italy’s death toll surpasses China’s, becoming the country with the highest number of coronavirus deaths in the world. On March 26 the deaths in Italy are more than the double of those of China (8,215 deaths in Italy, vis 3,287 deaths in China). Conclusion. Poor management of medium cases, in accordance with WHO guidelines, inevitably leads to overload of intensive care units. The progression of clusters in Southern Italy is more pronounced in Campania, Puglia and Sicily. The main cause of the high mortality would be attributable to the collapse of the Italian health system.